The Barrens weren't known as such simply for their lack of people, but for their lack of easy targets. This part of the barrens was simply a bad neighborhood, and when people were on edge around each other, it made it hard for a predator to take advantage of them.
The streets had clearly seen better days. Broken glass, graffiti and boarded up windows seemed to be the norm. It was the kind of place kindred usually wouldn't bother with, unless they had nowhere else to go. Or they were after such an individual.
Lobo Argost Liara Shepard